Sridhar, R., Bond, V., Dunmore-Griffith, J., Cousins, V. M., Zhang, R., & Millis, R. M. (2017). Relationship between aerobic fitness, the serum IGF-1 profiles of healthy young adult african american males, and growth of prostate cancer cells. American Journal of Men’s Health,<\/i>11<\/i>(1), 92-98.<\/p>\n
The growth of prostate tumors is mediated by the bioavailability of androgens and insulin-like growth factors. This study tested the hypothesis that healthy young adult African American men exhibiting low aerobic capacity (fitness) have serum insulin-like growth Factor-1 (IGF-1) and testosterone levels that promote growth of prostate cancer cells. A cross-sectional data research design was used to study groups of 18- to 26-year-old healthy men exhibiting low and moderate aerobic fitness, based on their peak oxygen consumption (VO2peak). The individual serum levels of IGF-1, IGF-1 binding protein-3 (IGFBP-3), and testosterone were measured. In vitro growth of androgen-dependent LNCaP prostate tumor cells was measured after incubation in culture medium fortified with each subject\u2019s serum. Aerobic capacity was significantly greater in the moderate-fitness group than in the low-fitness group without an intergroup difference in body mass index. The serum IGF-1 concentration was significantly higher in the low-fitness group in the absence of an intergroup difference in serum testosterone. The serum IGFBP-3 concentration was significantly lower in the low-fitness group. Prostate tumor cell growth was significantly greater in the cultures incubated in media containing the sera of the low-fitness group than in the sera of the moderate-fitness group. These findings suggest that moderate aerobic fitness in young adults may decrease the circulating levels of free IGF-1 and lower the potential to support growth of prostate cancer cells.<\/p>\n
Full article can be found here:<\/p>\n
http:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/1557988315587740<\/p>\n","protected":false},"excerpt":{"rendered":"
Sridhar, R., Bond, V., Dunmore-Griffith, J., Cousins, V. M., Zhang, R., & Millis, R. M. (2017). Relationship between aerobic fitness, the serum IGF-1 profiles of healthy young adult african american males, and growth of prostate cancer cells. American Journal of Men’s Health,11(1), 92-98. The growth of prostate tumors is mediated… read more<\/span> <\/i><\/a><\/p>\n","protected":false},"author":225,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[208],"tags":[1942,2057,2058,2059,2060,2061,2062,2063,2064],"class_list":{"0":"post-3667","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-physical-health-ph","7":"tag-1942","8":"tag-cancer","9":"tag-fitness","10":"tag-jacquelyn-dunmore-griffith","11":"tag-rajagopalan-sridhar","12":"tag-renshu-zhang","13":"tag-richard-m-millis","14":"tag-valerie-m-cousins","15":"tag-vernon-bond","16":"entry"},"_links":{"self":[{"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/posts\/3667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/users\/225"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/comments?post=3667"}],"version-history":[{"count":0,"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/posts\/3667\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/media?parent=3667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/categories?post=3667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.edb.utexas.edu\/bmerc\/wp-json\/wp\/v2\/tags?post=3667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}